The outside of the Center for Disease Control and Prevention (CDC) fundamental campus in Atlanta, Georgia, U.S., Aug. 27, 2025.
Alyssa Pointer | Reuters
The Centers for Disease Control and Prevention is facing a leadership upheaval — and at the middle of the shakeup is concern concerning the agency’s approach to vaccines and U.S. public health.
The White House on Thursday said President Donald Trump had fired CDC Director Susan Monarez after she refused to resign. Lawyers for Monarez said she was “targeted” for “protecting the general public over serving a political agenda.”
Meanwhile, 4 other top health officials on the CDC announced Wednesday they were quitting the agency. That features Demetre Daskalakis, director of the National Center for Immunization and Respiratory Diseases, who said he could now not serve due to the “weaponizing of public health.”
Former Centers for Disease Control and Prevention (CDC) Chief Medical Officer Debra Houry, former National Center for Immunization and Respiratory Diseases Director Demetre Daskalakis, and former National Center for Emerging and Zoonotic Infectious Diseases Director Daniel Jernigan hold flowers and react after they appeared during a protest, a day after the White House fired CDC director Susan Monarez and several other top officials resigned, in Atlanta, Georgia, U.S., Aug. 28, 2025.
Alyssa Pointer | Reuters
The lack of those respected leaders and efforts to oust Monarez follow a string of measures by Health and Human Services Secretary Robert F. Kennedy Jr. – a outstanding vaccine skeptic – to overhaul federal health agencies and alter immunization policy within the U.S. That features mass firings, gutting a key government vaccine panel, canceling studies on mRNA shot technology and hiring those with like-minded views.
Kennedy has an extended track record of creating misleading and false statements concerning the safety of vaccine shots, but in his current role, he wields enormous power over the agencies that regulate the immunizations and determine each who can get them and which of them insurance policy should cover.
Dr. Georges Benjamin, executive director of the American Public Health Association, said the leadership overhaul on the CDC represents Kennedy’s “failed leadership and reckless mismanagement,” adding that he has a “blatant disregard for science and evidence-based public health.”Â
The agency can also be reeling from funding cuts and an Aug. 8 attack by a gunman at its headquarters in Atlanta.
Some health policy experts said the leadership exodus could further erode the general public’s trust in an agency that’s answerable for detecting disease outbreaks and guiding state and native health departments when needed.
“This must be seen on top of a raft of the way that CDC has been weakened and undermined, perhaps irreversibly,” Lawrence Gostin, professor of public health law at Georgetown University, told CNBC.Â
“Throughout all of those years, CDC has been independent and the jewel within the crown of American science. That is literally all crumbling as we speak,” he said. “This is nearly the definition of politics undermining science.”
Top official highlights vaccine concerns
Daskalakis was among the many officials to explicitly highlight concerns with the views held by Kennedy and his staff, which he said challenged his ability to proceed in his role on the agency.
“I’m unable to serve in an environment that treats CDC as a tool to generate policies and materials that don’t reflect scientific reality and are designed to harm moderately than to enhance the general public’s health,” Daskalakis said in his resignation letter, which was posted on X.
He said the CDC’s recent changes to the adult and youngsters’s immunization schedule “threaten the lives of the youngest Americans and pregnant people.”
High-ranking members of the Centers for Disease Control and Prevention (CDC), wearing uniform, salute former CDC Chief Medical Officer Debra Houry, former National Center for Immunization and Respiratory Diseases Director Demetre Daskalakis, and former National Center for Emerging and Zoonotic Infectious Diseases Director Daniel Jernigan, a day after the White House fired CDC Director Susan Monarez and several other top officials resigned, in Atlanta, Georgia, U.S., Aug. 28, 2025.
Alyssa Pointer | Reuters
In May, Kennedy said the CDC removed Covid vaccines from the list of shots really helpful for healthy pregnant women and youngsters. An updated guidance days later said shots “may” be given to those groups.
Daskalakis said the information analyses that supported the change have “never been shared with the CDC despite my respectful requests to HHS and other leadership.” He also said HHS circulated a “regularly asked questions” document written to support Kennedy’s decision without input from CDC subject material experts, and that it cited studies “that didn’t support the conclusions that were attributed to those authors.”
On Wednesday, the Food and Drug Administration approved the most recent round of Covid vaccines just for those at higher risk of great illness, marking one other shift in policy around those shots for the reason that pandemic began.
Shares of Covid vaccine makers dipped on Thursday. Moderna’s stock fell greater than 3%, while shares of Pfizer fell around 2%.Â
Those corporations and other drugmakers have been bracing for changes to vaccine and public health policy since Trump first named Kennedy as his pick to guide HHS in November. The CDC’s leadership shakeup only adds to the uncertainty within the pharmaceutical industry, which can also be grappling with Trump’s drug pricing policies.Â
Kennedy tried to distance himself from his previous views about vaccines and other health policies during his Senate confirmation hearings back in January, claiming that he is not “anti-vaccine” and wouldn’t make it “difficult or discourage people from taking” routine shots for measles and polio.
But a few of Kennedy’s recent efforts appear to reflect his vaccine-critical views. For instance, Kennedy in August argued that mRNA vaccines – the technology utilized in Covid shots – are ineffective and advocated for the event of other jabs that use other “safer” platforms.
Years of research support the effectiveness of mRNA Covid vaccines, and the technology is now approved to be used in shots against respiratory syncytial virus.
Threat to public healthÂ
Former National Center for Immunization and Respiratory Diseases Director Demetre Daskalakis, next to former National Center for Emerging and Zoonotic Infectious Diseases Director Daniel Jernigan, speaks to the media during a protest, a day after the White House fired CDC director Susan Monarez and several other top officials resigned, in Atlanta, Georgia, U.S., Aug. 28, 2025.
Alyssa Pointer | Reuters
As changes roll through the CDC, concerns over a threat to public health and protocol are growing.
Daskalakis slammed the means by which HHS and other CDC leadership have communicated major policy changes. For instance, Kennedy announced he was firing the whole thing of the Advisory Committee on Immunization Practices – a panel of vaccine advisors to the CDC – through an X post and op-ed “moderately than direct communication with these worthwhile experts,” Daskalakis said.Â
He said he believed there can be a possibility to temporary Kennedy on key topics resembling measles, avian influenza and the approach to the respiratory virus season. But Daskalakis said seven months into the brand new administration, no CDC subject material expert from his center had briefed Kennedy.Â
“I’m unsure who the Secretary is listening to, nevertheless it is kind of definitely to not us,” he said. “Unvetted and conflicted outside organizations appear to be the sources HHS use over the gold standard science of CDC and other reputable sources.”
Former Centers for Disease Control and Prevention (CDC) Chief Medical Officer Debra Houry, followed by former National Center for Immunization and Respiratory Diseases Director Demetre Daskalakis, and former National Center for Emerging and Zoonotic Infectious Diseases Director Daniel Jernigan, reacts during a protest, a day after the White House fired CDC director Susan Monarez and several other top officials resigned, in Atlanta, Georgia, U.S., Aug. 28, 2025.
Alyssa Pointer | Reuters
Dr. Debra Houry, who also resigned Wednesday from her post because the CDC’s chief medical officer, similarly said that senior leaders “never were in a position to temporary the Secretary” on any of the problems the agency deals with.
“The CDC scientists are top notch and excellent,” she told MSNBC in an interview. “What we’d even have preferred was to have more interactions with the secretary.”
Houry added that “over the past few months, things on the CDC have been really difficult relating to having science and data driven decisions.”
As longtime experts leave the CDC, the specter of infectious diseases is growing. While measles cases are ticking up within the U.S. again, bird flu is spreading in cattle. The primary human case of the flesh-eating parasite “Recent World screwworm” has been detected within the country.
The departures could “make our public health less assured,” Benjamin of the American Public Health Association said.
Susan Monarez, U.S. President Donald Trump’s nominee to be director of the Centers for Disease Control and Prevention, testifies before a Senate Health, Education, Labor, and Pensions Committee confirmation hearing on Capitol Hill in Washington, D.C., U.S., June 25, 2025.
Kevin Mohatt | Reuters
He said the leadership disruption also raises concerns concerning the nation’s ability to detect and reply to an emerging infectious disease spreading since the CDC is the “glue that holds” individual doctors and state and native health departments together.
“I’m anxious that we can’t know in time, and that we’ll be chasing that disease for much longer than we must always,” Benjamin said.Â
Benjamin said he has “little confidence” that the Trump administration will find someone “highly competent” with relevant experience to exchange Monarez.Â
“It obviously all has enormous implications for the health and well being of the general public, and large implications across the funds of our nation,” he said. “Prevention and wellness saves us money, and public health is the most effective buy.”






